Minor Reaction

• Some users of Nonoxynol-9 may experience relatively "minor" reactions to the spermicide, including a genital rash, itching or a burning sensation (especially in men when urinating). In most cases, this occurs because the person's body has identified Nonoxynol-9 as a potential toxin and is rushing histamines to the affected area in an attempt to control the "attack." It is these histamines that make the rash and itching appear as the affected tissue swells and reddens.
  
  

Severe Reaction

• In some rare cases, severe reactions may occur, including swelling of the soft tissues of the genitals and a painful irritation or "burning" sensation. Much like the minor reactions, these reactions are cause by histamines, but they are more severe because your body is overreacting to the topical ointment.
  
  

Life-Threatening Reactions

• There is a possibility, though slim, that Nonoxynol-9 may induce a full anaphylactic reaction. In anaphylaxis, a person may experience shortness of breath, difficulty breathing, and/or "wheezing"; swelling of the tongue or throat; rapid heart rate; dramatic change in blood pressure; fainting or dizziness. In these cases, it is imperative that emergency medical personnel be summoned immediately as people experiencing anaphylaxis can die without immediate medical attention.
  
  

Other Reactions

• Some women have reported a watery discharge for up to 24 hours after intercourse when exposed to Nonoxynol-9. This discharge may keep the genitals and underclothes moist, causing external irritation. It may be advisable to switch to a spermicide with a different ingredient or to use non-spermicidal contraceptives if this occurs.
  
  

Prevention/Solution

• Though there is no "cure" for allergies, the easiest prevention is to cease using Nonoxynol-9 spermicide. In the case of accidental exposure resulting in a severe reaction, emergency medical personnel may administer epinephrine, an injectable drug that arrests the worst of the symptoms, thus allowing physicians to treat the patient.