Treatment of T1D Complicated by Problematic Hypoglycemia
Problematic hypoglycemia is another complication of long-term T1D, causing morbidity and mortality in a significant proportion of patients. It is important to screen patients for problematic hypoglycemia using validated tools and to implement individualized therapeutic targets based on the balance between glycemic control and hypoglycemia risk. Problematic hypoglycemia can be resolved with appropriate educational and technological interventions in most patients with acceptable glycemic control; however, in a subset of patients, transplants offer the only solution. Especially for that subset, existing interventions need to be more thoroughly evaluated and new therapies developed.
Conclusions
Problematic hypoglycemia is another complication of long-term T1D, causing morbidity and mortality in a significant proportion of patients. It is important to screen patients for problematic hypoglycemia using validated tools and to implement individualized therapeutic targets based on the balance between glycemic control and hypoglycemia risk. Problematic hypoglycemia can be resolved with appropriate educational and technological interventions in most patients with acceptable glycemic control; however, in a subset of patients, transplants offer the only solution. Especially for that subset, existing interventions need to be more thoroughly evaluated and new therapies developed.