GLP-1 Based Therapies: Effects Beyond Blood Glucose Control
It was shown in human trials that treatment with exenatide reduced fasting and post-prandial triglycerides, VLDL cholesterol and free fatty acid levels, in addition to improving markers of oxidative stress. Following cessation of treatment, lipid levels reverted to their pre-treatment values, indicating that ongoing treatment may be necessary to maintain beneficial effects. The improvement in post-prandial lipaemia may be a result of delayed gastric emptying and insulin-mediated inhibition of lipolysis.
GLP-1 Analogues and Cholesterol
It was shown in human trials that treatment with exenatide reduced fasting and post-prandial triglycerides, VLDL cholesterol and free fatty acid levels, in addition to improving markers of oxidative stress. Following cessation of treatment, lipid levels reverted to their pre-treatment values, indicating that ongoing treatment may be necessary to maintain beneficial effects. The improvement in post-prandial lipaemia may be a result of delayed gastric emptying and insulin-mediated inhibition of lipolysis.