Acute Leukemias of Ambiguous Origin
All possible combinations of MPAL can be observed, including B/myeloid, T/myeloid, B/T, or even rare B/T/myeloid. In a series of 100 cases of MPAL published by the EGIL, B/myeloid cases were most frequent, representing 59% of all MPAL cases. The frequencies of T/myeloid, B/T, or B/T/myeloid were 35%, 4%, and 2%, respectively. The blast cells in MPAL show a specific gene expression pattern, as illustrated by a microarray study of acute leukemias performed at St Jude Children's Research Hospital, where 35 childhood MPAL cases segregated in a specific cluster between B-acute lymphoblastic leukemia (B-ALL), T-acute lymphoblastic leukemia (T-ALL), and acute myeloid leukemia (AML).
What Possible Combinations of MPAL Occur and What Are Their Frequencies?
All possible combinations of MPAL can be observed, including B/myeloid, T/myeloid, B/T, or even rare B/T/myeloid. In a series of 100 cases of MPAL published by the EGIL, B/myeloid cases were most frequent, representing 59% of all MPAL cases. The frequencies of T/myeloid, B/T, or B/T/myeloid were 35%, 4%, and 2%, respectively. The blast cells in MPAL show a specific gene expression pattern, as illustrated by a microarray study of acute leukemias performed at St Jude Children's Research Hospital, where 35 childhood MPAL cases segregated in a specific cluster between B-acute lymphoblastic leukemia (B-ALL), T-acute lymphoblastic leukemia (T-ALL), and acute myeloid leukemia (AML).