The Evidence for Symptomatic Treatments in ALS
Cognitive problems are detectable in approximately 50% of patients. Recent genetic advances, such as discovery of the C9orf72 mutation, have established pathological links between ALS and frontotemporal dementia. Cognitive problems are important, as they confer a worse prognosis, make activities of daily living more difficult, produce additional burdens for caregivers who may consequently require more support and influence capacity for difficult decision-making. Rapid identification is facilitated by screening tools, such as Edinburgh Cognitive Assessment Scoring. Treatment is difficult; neuropsychological testing may clarify domains affected and enable occupational therapists to provide practical strategies.
Cognition
Cognitive problems are detectable in approximately 50% of patients. Recent genetic advances, such as discovery of the C9orf72 mutation, have established pathological links between ALS and frontotemporal dementia. Cognitive problems are important, as they confer a worse prognosis, make activities of daily living more difficult, produce additional burdens for caregivers who may consequently require more support and influence capacity for difficult decision-making. Rapid identification is facilitated by screening tools, such as Edinburgh Cognitive Assessment Scoring. Treatment is difficult; neuropsychological testing may clarify domains affected and enable occupational therapists to provide practical strategies.