Itraconazole

• Itraconazole is a drug you can give your dog take orally. It is the safest treatment for blastomycosis, but it is expensive and must be given for at least 60 days and up to 90 days. According to the Dog Owner's Guide (see References), the total cost of the treatment for a 40-lb. dog could exceed $1,000. The drug is dosed based on weight, so the costs would be even more with larger dogs.
  
  Some possible side effects of itraconazole include problems with the dog's liver, skin lesions and swelling of the legs.
  
  

Amphotericin B

• Amphotericin B is a drug that is usually administered by a slow intravenous drip, so you would have to have your veterinarian administer it to the dog. It sometimes is given by injection. The drug is administered one to three times per week until the maximum dose is given. This is usually given to a dog that has an acute infection that is life threatening.
  
  Amphotericin B is hard on the dog's kidneys, so your vet will need to monitor your dog closely.
  
  

Ketoconazole

• Ketoconazole is another drug that is given orally. You can give this drug twice a day, and it is usually given for 10 to 14 days. It is often given in conjunction with amphotericin B so that less of the amphotericin B is needed.
  
  Although ketoconazole is cheaper than itraconazole, it has stronger side effects and is generally not as effective. The side effects can include liver problems, weight loss, nausea and vomiting. It can also be harmful to pregnant dogs and can cause fertility problems in males.