Hyaluronic acid is a straight chain acid mucopolysaccharide isolated from bovine vitreous with the connection between ascetyl glucosamine and glucose aldehydic acid disaccharide unit made by the United States Meyer in 1934.HA exists in human and animal skin, serum, tissue interstitial fluid, with a unique skin moisturizing, nutrition, anti-aging, stability, emulsification, anti-bacterial anti-inflammatory and promote wound healing and drug delivery and other special functions, is in Japan chemical, pharmaceutical, chemical and biological areas such as health food and extremely versatile, excellent functional biochemicals.
Earlier, as many animal tissues and organs HA as raw materials in the system, a complex production process, low output and high cost, and therefore prices are too expensive, so its application is limited to medical and biochemical glutathione fields. HA prepared with microbial fermentation technology is developing rapidly, increasing production, and its scope of application of gradually in Japan, health food and other areas will be expanded. 1980s, HA on its excellent moisturizing, nutrition, skin and other special performance by the international cosmetics industry attention. Since then, the HA as a series of special features cosmetic raw materials have come out, clearly showing that HA functions as a new cosmetic raw materials strong development momentum.
The basic chemical structure of HA is a D-N-acetyl-D-glucosamine and glucuronic acid as structural unit, and a 1,4-glycosidic bond alternating links into a straight chain polymer acid mucopolysaccharide compounds 3'6 J, as a white powder, no special smell, relative molecular mass is generally 0.8 lo6 ~ 2.0 lo6, rotation: a 74o (25 , 0.025% water). It can be slow but eventually completely soluble in water to form a sticky, slightly milky white or colorless solution, insoluble in organic solvents. HA strong compatibility, compatibility is good, almost any water can be added to the cosmetic matrix. Typically, cosmetic grade HA products glucuronic acid mass fraction /> 42%, protein mass fraction 0.1%, loss on drying 10%, 0.1% aqueous solution of pH 6.0 ~ 7.5, burning Residue on ignition
Earlier, as many animal tissues and organs HA as raw materials in the system, a complex production process, low output and high cost, and therefore prices are too expensive, so its application is limited to medical and biochemical glutathione fields. HA prepared with microbial fermentation technology is developing rapidly, increasing production, and its scope of application of gradually in Japan, health food and other areas will be expanded. 1980s, HA on its excellent moisturizing, nutrition, skin and other special performance by the international cosmetics industry attention. Since then, the HA as a series of special features cosmetic raw materials have come out, clearly showing that HA functions as a new cosmetic raw materials strong development momentum.
The basic chemical structure of HA is a D-N-acetyl-D-glucosamine and glucuronic acid as structural unit, and a 1,4-glycosidic bond alternating links into a straight chain polymer acid mucopolysaccharide compounds 3'6 J, as a white powder, no special smell, relative molecular mass is generally 0.8 lo6 ~ 2.0 lo6, rotation: a 74o (25 , 0.025% water). It can be slow but eventually completely soluble in water to form a sticky, slightly milky white or colorless solution, insoluble in organic solvents. HA strong compatibility, compatibility is good, almost any water can be added to the cosmetic matrix. Typically, cosmetic grade HA products glucuronic acid mass fraction /> 42%, protein mass fraction 0.1%, loss on drying 10%, 0.1% aqueous solution of pH 6.0 ~ 7.5, burning Residue on ignition