- The main physical side effects of Cymbalta, regardless of why the medication is initially prescribed, are headache, nausea, dry mouth, constipation, increased sweating, sleepiness or fatigue, and decreased appetite.
- People taking Cymbalta for generalized anxiety disorder are more likely to experience dizziness and vomiting than those taking the drug for depression. In clinical trials, 15.3 percent of patients receiving Cymbalta for this reason discontinued the drug because of its adverse effects.
- Patients in clinical trials being treated for diabetic peripheral neuropathic pain and fibromyalgia discontinued the drug at rates of 14.3 and 19.5 percent, respectively. Nausea, sleepiness, fatigue and dizziness were the most common reasons for discontinuation.
- Less than 5 percent of patients experienced heart palpitations, blurred vision, abdominal pain, weight loss, tremor and sexual side effects.
- Serious reactions may be due to allergies, undiagnosed conditions, drug interactions or due to an unknown reason. For Cymbalta, these serious reactions include liver problems such as jaundice, hepatitis and liver failure; sharp drops in blood pressure that may be accompanied by fainting; and abnormal bleeding or clotting, which can include hemorrhages. If administered with other anti-depressants or psychotropic drugs, serotonin levels may be so high that they become toxic, causing fast heartbeat, high temperature, muscle rigidity and lack of coordination.
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